TFDP1 Gene Summary [Human]

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

Details

Type
Processed Transcript
Official Symbol
TFDP1
Official Name
transcription factor Dp-1 [Source:HGNC Symbol;Acc:HGNC:11749]
Ensembl ID
ENSG00000198176
Bio databases IDs NCBI: 7027 Ensembl: ENSG00000198176
Aliases transcription factor Dp-1, down-regulated in liver cancer stem cells
Synonyms DILC, DP-1, DRTF1, TB2/DP1, transcription factor Dp-1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TFDP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
  • DP-conserved box domain
  • transcription regulator
  • dimerization domain
  • Dimerization domain of DP
  • DNA binding domain
  • nucleic acid binding
  • transcription factor binding
  • protein domain specific binding
  • protein binding
  • sequence-specific DNA binding
  • DEF box
  • phosphorylation site
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • E2F protein-binding domain
  • double-stranded DNA binding
  • E2F/DP family winged-helix DNA-binding domain
  • transcription factor activity

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-insulin-dependent diabetes mellitus
  • osteogenesis imperfecta type III
  • exencephaly
  • colorectal cancer
  • hereditary gingival fibromatosis
  • growth failure
  • Waldenström macroglobulinemia
regulated by
  • WNT3A
  • adenosine triphosphate
  • R-WIN 55,212
  • TGFB1
  • TP53
  • Lmp2a
  • wortmannin
  • lipopolysaccharide
  • tetradecanoylphorbol acetate
  • MDM2
regulates
role in cell
  • proliferation
  • cell death
  • expression in
  • growth
  • G1 phase
  • quantity
  • G1/S phase transition
  • apoptosis
  • number
  • cell cycle progression

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • Cytoplasm
  • cytosol
  • nucleoplasm
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TFDP1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of G1/S transition of mitotic cell cycle
  • epidermis development
  • regulation of DNA biosynthetic process
  • regulation of transcription, DNA-dependent
  • transcription from RNA polymerase II promoter
  • anoikis
  • negative regulation of fat cell proliferation
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • Rb-E2F complex
  • cytoplasm
  • cytosol
  • chromatin
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • sequence-specific DNA binding transcription factor activity
  • protein domain specific binding
  • protein binding
  • RNA polymerase II regulatory region sequence-specific DNA binding
  • core promoter proximal region sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  • sequence-specific DNA binding RNA polymerase II transcription factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.