THBS3 Gene Summary [Human]
The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]
Details
| Type | Retained Intron |
| Official Symbol | THBS3 |
| Official Name | thrombospondin 3 [Source:HGNC Symbol;Acc:HGNC:11787] |
| Ensembl ID | ENSG00000169231 |
| Bio databases IDs | |
| Aliases | thrombospondin 3 |
| Synonyms | LOC100503360, thrombospondin 3, TSP3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THBS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin C-terminal region
- Coiled coil region of thrombospondin
- LamG
- EGF domain
- protein binding
- heparin binding
- thrombospondin type 3 repeat
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THBS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- growth plate cartilage development
- bone trabecula formation
- ossification involved in bone maturation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heparin binding
- extracellular matrix structural constituent