ACKR3 Gene Summary [Human]
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ACKR3 |
| Official Name | atypical chemokine receptor 3 [Source:HGNC Symbol;Acc:HGNC:23692] |
| Ensembl ID | ENSG00000144476 |
| Bio databases IDs | |
| Aliases | atypical chemokine receptor 3 |
| Synonyms | atypical chemokine receptor 3, CMKOR1, CXC-R7, GPR159, LOC105373991, RDC-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACKR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-X-C chemokine binding
- C-X-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- scavenger receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the ACKR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- advanced cancer
- cancer
- colorectal cancer
- plexiform neurofibroma
- osteoarthritis
- oculomotor-abducens synkinesis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
role in cell
- proliferation
- apoptosis
- activation in
- expression in
- migration
- growth
- phosphorylation in
- activity
- invasion by
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- cellular membrane
- endosomes
- clathrin-coated pits
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACKR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- oculomotor nerve development
- cell adhesion
- vasculogenesis
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
- immune response
- angiogenesis
- chemokine-mediated signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- calcium-mediated signaling
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- coated pit
- intracellular membrane-bounded organelle
- external side of plasma membrane
- recycling endosome
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- coreceptor activity
- C-X-C chemokine binding
- protein binding
- C-C chemokine receptor activity
- scavenger receptor activity
- C-X-C chemokine receptor activity