PTAFR Gene Summary [Human]
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | PTAFR |
| Official Name | platelet activating factor receptor [Source:HGNC Symbol;Acc:HGNC:9582] |
| Ensembl ID | ENSG00000169403 |
| Bio databases IDs | |
| Aliases | platelet activating factor receptor |
| Synonyms | PAF-R, PAF receptor, platelet-activating factor receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTAFR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- phospholipid binding
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- protein kinase binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- lipopolysaccharide binding
- cytoplasmic domain
- transmembrane domain
- platelet activating factor receptor
- 7 transmembrane receptor (rhodopsin family)
- G-protein binding domain
Pathways
Biological processes and signaling networks where the PTAFR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- atopic dermatitis
- Huntington disease
- neoplasia
- airway hyperresponsiveness
- hypersensitivity reaction type I
- edema
- pneumococcal pneumonia
- immunodeficiency
- endometrioid ovarian cancer
role in cell
- expression in
- proliferation
- survival
- apoptosis
- growth
- quantity
- activation in
- invasion by
- formation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- secretory granule membrane
- tertiary granule membrane
- perikaryon
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTAFR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- positive regulation of smooth muscle cell proliferation
- chemotaxis
- inflammatory response
- immune response
- cellular response to fatty acid
- transcytosis
- response to symbiotic bacterium
- positive regulation of tumor necrosis factor production
- cellular response to gravity
- G-protein coupled receptor signaling pathway
- negative regulation of blood pressure
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of cellular extravasation
- positive regulation of inositol phosphate biosynthetic process
- regulation of transcription from RNA polymerase II promoter
- parturition
- positive regulation of neutrophil degranulation
- inositol trisphosphate biosynthetic process
- cellular response to cAMP
- lipopolysaccharide-mediated signaling pathway
- positive regulation of interleukin-6 production
- G-protein coupled purinergic nucleotide receptor signaling pathway
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- membrane
- tertiary granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- lipopolysaccharide receptor activity
- protein binding
- G-protein coupled purinergic nucleotide receptor activity
- phospholipid binding
- mitogen-activated protein kinase binding
- platelet activating factor receptor activity
- lipopolysaccharide binding