ALCAM Gene Summary [Human]
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | ALCAM |
| Official Name | activated leukocyte cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:400] |
| Ensembl ID | ENSG00000170017 |
| Bio databases IDs | |
| Aliases | activated leukocyte cell adhesion molecule |
| Synonyms | 201951 at, activated leukocyte cell adhesion molecule, AI853494, ALCAM isoform 1, BEN, CD166, DM-GRASP, HB2, MEMD, MuSC, SC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALCAM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin V-Type
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cancer
- liver cancer
- experimental autoimmune encephalomyelitis
- delayed hypersensitive reaction
- hemangioma
- angiomatosis
- colorectal cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- cell viability
- activation in
- apoptosis
- expression in
- adhesion
- quantity
- differentiation
- binding
- proliferation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- extracellular vesicles
- cell surface
- cellular membrane
- immunological synapses
- plasma membrane extracellular face
- membrane rafts
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALCAM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinal ganglion cell axon guidance
- motor axon guidance
- signal transduction
- heterophilic cell-cell adhesion
- adaptive immune response
- cell adhesion
- axon extension involved in axon guidance
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular vesicular exosome
- focal adhesion
- external side of plasma membrane
- T cell receptor complex
- neuronal cell body
- axon
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- receptor binding