RNF139 Gene Summary [Human]
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RNF139 |
| Official Name | ring finger protein 139 [Source:HGNC Symbol;Acc:HGNC:17023] |
| Ensembl ID | ENSG00000170881 |
| Bio databases IDs | |
| Aliases | ring finger protein 139, translocation in renal carcinoma, chromosome 8 |
| Synonyms | 4930555P18RIK, HRCA1, RCA1, ring finger protein 139, TRC8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF139 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- protease binding
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- ubiquitin-like protein transferase activity
- RING-type zinc-finger
- TRC8 N-terminal domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- renal cell cancer
- atopic dermatitis
role in cell
- degradation in
- ubiquitination in
- proliferation
- expression in
- binding in
- processing in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF139 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein destabilization
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of ER to Golgi vesicle-mediated transport
- negative regulation of cell proliferation
- negative regulation of translation
- protein ubiquitination
- regulation of protein processing
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endomembrane system
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- signaling receptor activity
- protease binding
- small conjugating protein ligase activity