Rnf139 Gene Summary [Mouse]
Predicted to enable protease binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including proteasomal protein catabolic process; protein destabilization; and regulation of protein metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex. Predicted to be active in endomembrane system. Is expressed in bladder; central nervous system; testis; and ureter. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human RNF139 (ring finger protein 139). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf139 |
| Official Name | ring finger protein 139 [Source:MGI Symbol;Acc:MGI:1923091] |
| Ensembl ID | ENSMUSG00000037075 |
| Bio databases IDs | |
| Aliases | ring finger protein 139 |
| Synonyms | 4930555P18RIK, HRCA1, RCA1, ring finger protein 139, TRC8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf139 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- protease binding
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- ubiquitin-like protein transferase activity
- RING-type zinc-finger
- TRC8 N-terminal domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- renal cell cancer
- atopic dermatitis
role in cell
- degradation in
- ubiquitination in
- proliferation
- expression in
- binding in
- processing in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf139 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein destabilization
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of ER to Golgi vesicle-mediated transport
- negative regulation of cell proliferation
- negative regulation of translation
- protein ubiquitination
- regulation of protein processing
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endomembrane system
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- signaling receptor activity
- protease binding
- small conjugating protein ligase activity