EIF3A Gene Summary [Human]
Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EIF3A |
| Official Name | eukaryotic translation initiation factor 3 subunit A [Source:HGNC Symbol;Acc:HGNC:3271] |
| Ensembl ID | ENSG00000107581 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3 subunit A |
| Synonyms | A830012B05RIK, Csma, EIF3, eIF3-p170, EIF3S10, eIF3-theta, eIF3-θ, Elf3-P162, eukaryotic translation initiation factor 3 subunit A, eukaryotic translation initiation factor 3, subunit A, mKIAA0139, P167, p180, p185, TIF32, ZH12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- winged helix-fold of PINT
- receptor tyrosine kinase binding
- Trichohyalin-plectin-homology domain
- Adhesion protein FadA
- translation initiation factor
- coiled-coil domain
- protein binding
- translation regulator
- RNA binding
Pathways
Biological processes and signaling networks where the EIF3A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- breast cancer
- gastric cancer
- keratoconus
- esophageal cancer
- cervical cancer
- alcoholic pancreatitis
- infection by vesicular stomatitis virus
role in cell
- expression in
- proliferation
- phosphorylation in
- synthesis in
- motility
- survival
- invasion
- replication in
- activity
- dissociation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- microtubules
- cytosol
- nucleoplasm
- nucleoli
- postsynaptic density
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation initiation complex
- negative regulation of ERK1 and ERK2 cascade
- translational initiation
- translation reinitiation
Cellular Component
Where in the cell the gene product is active
- multi-eIF complex
- postsynaptic density
- eukaryotic 48S preinitiation complex
- nucleolus
- nucleoplasm
- eukaryotic translation initiation factor 3 complex
- microtubule
- eukaryotic translation initiation factor 3 complex, eIF3m
- cytoplasm
- eukaryotic 43S preinitiation complex
- eukaryotic translation initiation factor 3 complex, eIF3e
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- protein binding
- structural molecule activity
- mRNA binding
- receptor tyrosine kinase binding