OSCAR Gene Summary [Human]
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | OSCAR |
| Official Name | osteoclast associated Ig-like receptor [Source:HGNC Symbol;Acc:HGNC:29960] |
| Ensembl ID | ENSG00000170909 |
| Bio databases IDs | |
| Aliases | osteoclast associated Ig-like receptor |
| Synonyms | mOSCAR, mOSCAR-M1, mOSCAR-M2, mOSCAR-M3, osteoclast associated Ig-like receptor, osteoclast associated receptor, PIGR3, RGD1559897 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OSCAR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- protein binding
- collagen receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
role in cell
- expression in
- differentiation
- number
- apoptosis
- function
- abnormal morphology
- lifespan
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- secretory granule lumen
- cell surface
- Extracellular Space
- organelle lumens
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OSCAR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast differentiation
- immune response-regulating signaling pathway
- collagen-activated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- specific granule lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- collagen receptor activity