TRIP10 Gene Summary [Human]
Enables identical protein binding activity. Predicted to be involved in actin cytoskeleton organization; endocytosis; and signal transduction. Located in nucleoplasm. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRIP10 |
| Official Name | thyroid hormone receptor interactor 10 [Source:HGNC Symbol;Acc:HGNC:12304] |
| Ensembl ID | ENSG00000125733 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor interactor 10, Cdc42-interacting protein |
| Synonyms | CIP4, Cip4/2, HSTP, STOT, STP, thyroid hormone receptor interactor 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIP10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- microtubule binding domain
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- HR1
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the TRIP10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- delayed hypersensitive reaction
role in cell
- cell death
- migration
- activation in
- activity
- function
- polarization
- invasion
- assembly
- formation
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- intracellular membrane-bounded organelle
- cell periphery
- cellular membrane
- Nucleus
- microtubules
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIP10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell communication
- signal transduction
- endocytosis
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- cell projection
- phagocytic cup
- lysosome
- nucleoplasm
- extracellular vesicular exosome
- cytoskeleton
- perinuclear region of cytoplasm
- cytoplasm
- cell cortex
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding