FUT3 Gene Summary [Human]
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | FUT3 |
| Official Name | fucosyltransferase 3 (Lewis blood group) [Source:HGNC Symbol;Acc:HGNC:4014] |
| Ensembl ID | ENSG00000171124 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 3 (Lewis blood group), galactoside 3(4)-L-fucosyltransferase |
| Synonyms | alpha (1,31,4) FUCOSYLTRANSFERASE, CD174, FT3B, fucosyltransferase 3 (Lewis blood group), FucT-III, LE, Les, α (1,31,4) FUCOSYLTRANSFERASE |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FUT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
- alpha(1,3)-fucosyltransferase
- Fucosyltransferase, N-terminal
- transmembrane domain
- fucosyltransferase
- enzyme
- protein binding
- Glycosyltransferase family 10 (fucosyltransferase) C-term
- galactoside 3-fucosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- metastasis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- cholelithiasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- gallbladder polyp
- prostate cancer
role in cell
- phosphorylation in
- binding
- activation in
- apoptosis
- proliferation
- migration
- activation
- synthesis in
- adhesion
- biosynthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- trans face of the Golgi apparatus
- trans Golgi network
- transport vesicles
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FUT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- fucosylation
- positive regulation of cell-cell adhesion
- protein N-linked glycosylation
- oligosaccharide biosynthetic process
- ceramide metabolic process
- oligosaccharide metabolic process
- macromolecule glycosylation
- regulation of cell migration
- cell-cell recognition
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- Golgi cisterna membrane
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
- protein binding
- fucosyltransferase activity
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
- alpha-(1->3)-fucosyltransferase activity