TRIM8 Gene Summary [Human]
This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | TRIM8 |
| Official Name | tripartite motif containing 8 [Source:HGNC Symbol;Acc:HGNC:15579] |
| Ensembl ID | ENSG00000171206 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 8, glioblastoma expressed ring finger protein, E3 ubiquitin-protein ligase TRIM8 |
| Synonyms | BB006755, FSGSNEDS, GERP, RNF27, tripartite motif-containing 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- protein kinase binding
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- protein homodimerization
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- liver cancer
- epithelial cancer
- Focal segmental glomerulosclerosis and neurodevelopmental syndrome
- hepatocellular carcinoma
- hereditary disorder
- prostatic carcinoma
- prostate cancer
- septic shock
- pyelonephritis
role in cell
- expression in
- activation in
- production in
- binding in
- hypertrophy
- autophagy by
- maintenance
- K6 polyubiquitination in
- K63 polyubiquitination in
- K33 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- granules
- cytosol
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- stem cell maintenance
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of autophagy
- negative regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- innate immune response
- protein K63-linked ubiquitination
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein homodimerization activity
- protein binding
- transcription coactivator activity
- mitogen-activated protein kinase kinase kinase binding