METTL18 Gene Summary [Human]
Enables heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Involved in peptidyl-lysine monomethylation; regulation of gene expression; and regulation of ribosome biogenesis. Located in cytosol and nucleolus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | METTL18 |
| Official Name | methyltransferase like 18 [Source:HGNC Symbol;Acc:HGNC:28793] |
| Ensembl ID | ENSG00000171806 |
| Bio databases IDs | |
| Aliases | methyltransferase like 18, histidine protein methyltransferase 1 |
| Synonyms | 2810422O20Rik, AsTP2, C1orf156, HPM1, methyltransferase 18, RPL3 N3(tau)-histidine, methyltransferase like 18, RGD1306783 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METTL18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- heat shock protein binding
- protein-histidine N-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METTL18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- regulation of translational elongation
- regulation of ribosome biogenesis
- peptidyl-lysine methylation
- peptidyl-lysine monomethylation
- regulation of rRNA processing
- peptidyl-histidine methylation, to form tele-methylhistidine
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- nucleolus
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- protein binding
- protein-histidine N-methyltransferase activity
- protein-lysine N-methyltransferase activity