PPIH Gene Summary [Human]
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPIH |
| Official Name | peptidylprolyl isomerase H [Source:HGNC Symbol;Acc:HGNC:14651] |
| Ensembl ID | ENSG00000171960 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase H, USA-CyP SnuCyp-20, cyclophilin H, U-snRNP-associated cyclophilin SunCyp-20, small nuclear ribonucleoprotein particle-specific cyclophilin H, rotamase H, peptidyl-prolyl cis-trans isomerase H, PPIase h |
| Synonyms | 1100001J08Rik, 2010111B15Rik, 4833408F11Rik, cyclophilin H, CYP-20, CYPH, D4WSU43E, peptidyl prolyl isomerase H, RGD1564921, SnuCyp-20, USA-CYP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidylprolyl isomerase
- cyclophilin catalytic pocket
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- ribonucleoprotein binding
- cyclosporin A binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the PPIH gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- protein peptidyl-prolyl isomerization
- protein folding
- positive regulation of viral genome replication
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- nuclear speck
- U4/U6 x U5 tri-snRNP complex
- U4/U6 snRNP
- spliceosomal complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- ribonucleoprotein complex binding