RARS1 Gene Summary [Human]
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RARS1 |
| Official Name | arginyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:9870] |
| Ensembl ID | ENSG00000113643 |
| Bio databases IDs | |
| Aliases | arginyl-tRNA synthetase 1, arginine tRNA ligase 1, cytoplasmic |
| Synonyms | 2610011N19Rik, 2610037E21Rik, Arginyl-tRNA synthetase, arginyl-tRNA synthetase 1, ArgRS, bone marrow macrophage tRNA synthetase, Cytoplasmic tRNA Synthetase, DALRD1, HLD9, RARS, RRS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RARS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- arginyl-tRNA synthetase
- tRNA synthetases class I (R)
- ATP binding
- enzyme
- protein binding
- amino acid binding
- class Ia aminoacyl tRNA synthetases anticodon binding domain
- binding protein
- DALR anticodon binding domain
- Arginyl tRNA synthetase N terminal domain
- arginine-tRNA ligase
- Arginyl tRNA synthetase N terminal dom
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- abdominal cancer
- non-small cell lung cancer
- COVID-19
- retroperitoneal cancer
- hypomyelinating leukodystrophy type 9
- leukodystrophy
- hereditary disorder
role in cell
- recruitment
- proliferation
- expression in
- production in
- migration
- invasion by
- binding in
- alternative splicing in
- consumption in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RARS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- arginyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- aminoacyl-tRNA synthetase multienzyme complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- arginine binding
- ATP binding
- protein binding
- arginine-tRNA ligase activity
- cadherin binding
- tRNA binding