TRIM40 Gene Summary [Human]
This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | TRIM40 |
| Official Name | tripartite motif containing 40 [Source:HGNC Symbol;Acc:HGNC:18736] |
| Ensembl ID | ENSG00000172524 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 40 |
| Synonyms | Gm319, Gm35, Gm865, LOC100364386, RNF35, tripartite motif-containing 40 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM40 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- zinc finger of C3HC4-type, RING
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM40 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein localization to nucleus
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of cell growth
- innate immune response
- protein neddylation
- negative regulation of protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- IkappaB kinase complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding