DAB1 Gene Summary [Human]
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | DAB1 |
| Official Name | DAB adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:2661] |
| Ensembl ID | ENSG00000173406 |
| Bio databases IDs | |
| Aliases | DAB adaptor protein 1, yotari |
| Synonyms | AI956902, C630028C02RIK, DAB adaptor protein 1, disabled 1, LOC100502604, mDab1, SCA37, scm, scr, scrambler, yot |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- protein interaction domain
- phosphoinositide 3-kinase binding
- SH2-domain binding
- protein binding activity, bridging
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the DAB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- coronary artery disease
- Alzheimer disease
- acute myeloid leukemia
- metabolic syndrome X
- hereditary spastic ataxia
- non-insulin-dependent diabetes mellitus
- insomnia
- idiopathic scoliosis
- streptococcal pharyngitis
role in cell
- expression in
- adhesion
- phosphorylation in
- migration
- synthesis in
- differentiation
- aggregation
- accumulation
- formation
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cell periphery
- apical compartment
- perinuclear region
- Plasma Membrane
- vesicles
- cytosol
- membrane ruffles
- growth cone
- synapse
- brush border
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte differentiation
- cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
- small GTPase mediated signal transduction
- ventral spinal cord development
- negative regulation of cell adhesion
- cerebellum structural organization
- positive regulation of neuron differentiation
- negative regulation of astrocyte differentiation
- hippocampus development
- radial glia guided migration of Purkinje cell
- negative regulation of JAK-STAT cascade
- JAK-STAT cascade
- adult walking behavior
- neuron migration
- negative regulation of axonogenesis
- axonogenesis
- Golgi localization
- dendrite development
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding