DCP2 Gene Summary [Human]
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | DCP2 |
| Official Name | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] |
| Ensembl ID | ENSG00000172795 |
| Bio databases IDs | |
| Aliases | decapping mRNA 2, nudix (nucleoside diphosphate linked moiety X)-type motif 20, M(7)GpppN-mRNA hydrolase |
| Synonyms | 2410015D23Rik, 5730537H01RIK, decapping mRNA 2, LOC100909830, LOC105379125, NUDT20, RGD1562909 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 5' phosphomonoester producing exoribonuclease
- A-box
- NUDIX domain
- pyrophosphatase
- 5'-3' exoribonuclease
- Dcp2, box A domain
- enzyme
- protein binding
- Box B domain
- NUDIX hydrolase superfamily
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- cell junction
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- Cytoplasm
- polysomes
- cytoplasmic aggregates
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- histone mRNA catabolic process
- deadenylation-dependent decapping of nuclear-transcribed mRNA
- regulation of mRNA stability
- negative regulation of telomere maintenance via telomerase
- mRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- cell junction
- RNA-induced silencing complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 5'-3' exoribonuclease activity
- protein binding
- telomeric RNA binding
- manganese ion binding
- exoribonuclease activity, producing 5'-phosphomonoesters