TADA2B Gene Summary [Human]
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | TADA2B |
| Official Name | transcriptional adaptor 2B [Source:HGNC Symbol;Acc:HGNC:30781] |
| Ensembl ID | ENSG00000173011 |
| Bio databases IDs | |
| Aliases | transcriptional adaptor 2B |
| Synonyms | ADA2B, ADA2(beta), ADA2(β), Gm145, MGC21874, RGD1561605, transcriptional adaptor 2B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TADA2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZZ
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- Myb-like DNA-binding domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TADA2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- regulation of DNA repair
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- SAGA-type complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription coactivator activity
- chromatin binding