HSPA6 Gene Summary [Human]
Enables enzyme binding activity; heat shock protein binding activity; and unfolded protein binding activity. Involved in cellular response to heat and protein refolding. Located in centriole and cytosol. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HSPA6 |
| Official Name | heat shock protein family A (Hsp70) member 6 [Source:HGNC Symbol;Acc:HGNC:5239] |
| Ensembl ID | ENSG00000173110 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 6 |
| Synonyms | heat shock protein family A (Hsp70) member 6, HSP70B, HSP70B', IDBP4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSPA6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fe-S protein assembly chaperone HscA
- cell shape determining protein, MreB/Mrl family
- MreB/Mbl protein
- Cell division protein FtsA
- heat shock protein binding
- chaperone protein DnaK
- enzyme binding
- enzyme
- protein binding
- Hsp70 protein
- ATPase
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HSPA6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- Alzheimer disease
- epileptic seizure
- flu
role in cell
- expression in
- phosphorylation in
- response by
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- centriole
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSPA6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to heat
- cellular heat acclimation
- chaperone mediated protein folding requiring cofactor
- protein refolding
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- centriole
- blood microparticle
- cytosol
- secretory granule lumen
- signalosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- heat shock protein binding
- protein binding involved in protein folding
- protein binding
- unfolded protein binding
- enzyme binding