EIF5A2 Gene Summary [Human]
Predicted to enable translation elongation factor activity. Predicted to be involved in positive regulation of translational elongation. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EIF5A2 |
| Official Name | eukaryotic translation initiation factor 5A2 [Source:HGNC Symbol;Acc:HGNC:3301] |
| Ensembl ID | ENSG00000163577 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 5A2 |
| Synonyms | 9630038B20, eIF5AII, eukaryotic translation initiation factor 5A2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF5A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- translation elongation factor IF5A
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the EIF5A2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- non-small cell lung cancer
- celiac disease
role in cell
- migration
- expression in
- phosphorylation in
- growth
- cell viability
- invasion by
- autophagy in
- senescence
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF5A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational termination
- spermatogenesis
- translational elongation
- positive regulation of translational elongation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- translation elongation factor activity
- ribosome binding