NDNF Gene Summary [Human]
Predicted to enable heparin binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of apoptotic process; and nitric oxide mediated signal transduction. Located in extracellular space. Implicated in hypogonadotropic hypogonadism. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NDNF |
| Official Name | neuron derived neurotrophic factor [Source:HGNC Symbol;Acc:HGNC:26256] |
| Ensembl ID | ENSG00000173376 |
| Bio databases IDs | |
| Aliases | neuron derived neurotrophic factor |
| Synonyms | A930038C07Rik, AABR07060833.1, C4orf31, DKZFP564G112, epidermacan, FLJ23191, HH25, neuron-derived neurotrophic factor, NORD, RGD1311080 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDNF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neuron-derived neurotrophic factor, first Fn(III) domain
- Neuron-derived Neurotrophic Factor C-terminal
- heparin binding
- glycosaminoglycan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- hypogonadotropic hypogonadism 25 with anosmia
- Richter syndrome
- atrial premature complex
role in cell
- activation in
- apoptosis
- migration
- survival
- development
- organization
- network formation
- response by
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NDNF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus
- nitric oxide mediated signal transduction
- vascular wound healing
- cellular response to fibroblast growth factor stimulus
- negative regulation of neuron apoptotic process
- neuron migration
- response to ischemia
- angiogenesis
- extracellular matrix organization
- positive regulation of cell-substrate adhesion
- positive regulation of neuron projection development
- cellular response to hypoxia
- negative regulation of endothelial cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- heparin binding