Ndnf Gene Summary [Mouse]
Enables heparin binding activity. Involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus; response to ischemia; and vascular wound healing. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including brain; embryo mesenchyme; intervertebral disc; lung; and molar. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NDNF (neuron derived neurotrophic factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndnf |
| Official Name | neuron-derived neurotrophic factor [Source:MGI Symbol;Acc:MGI:1915419] |
| Ensembl ID | ENSMUSG00000049001 |
| Bio databases IDs | |
| Aliases | neuron-derived neurotrophic factor |
| Synonyms | A930038C07Rik, AABR07060833.1, C4orf31, DKZFP564G112, epidermacan, FLJ23191, HH25, neuron-derived neurotrophic factor, NORD, RGD1311080 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndnf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neuron-derived neurotrophic factor, first Fn(III) domain
- Neuron-derived Neurotrophic Factor C-terminal
- heparin binding
- glycosaminoglycan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- hypogonadotropic hypogonadism 25 with anosmia
- Richter syndrome
- atrial premature complex
regulates
- AKT
- nitric oxide
- NOS3
role in cell
- activation in
- apoptosis
- migration
- survival
- development
- organization
- network formation
- response by
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndnf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus
- nitric oxide mediated signal transduction
- vascular wound healing
- cellular response to fibroblast growth factor stimulus
- negative regulation of neuron apoptotic process
- neuron migration
- response to ischemia
- angiogenesis
- extracellular matrix organization
- positive regulation of cell-substrate adhesion
- positive regulation of neuron projection development
- cellular response to hypoxia
- negative regulation of endothelial cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- heparin binding