INSM1 Gene Summary [Human]
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | INSM1 |
| Official Name | INSM transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:6090] |
| Ensembl ID | ENSG00000173404 |
| Bio databases IDs | |
| Aliases | INSM transcriptional repressor 1 |
| Synonyms | IA-1, INSM transcriptional repressor 1, INSULINOMA ASSOCIATED 1, LOC100912563 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INSM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- small cell lung cancer
- neuroendocrine lung tumor
- small cell cervical cancer
role in cell
- apoptosis
- expression in
- proliferation
- differentiation
- binding in
- migration
- number
- cell cycle progression
- development
- transdifferentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INSM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- neuron differentiation
- negative regulation of cell proliferation
- regulation of protein complex assembly
- positive regulation of cell differentiation
- norepinephrine biosynthetic process
- adrenal chromaffin cell differentiation
- pancreatic A cell differentiation
- type B pancreatic cell development
- negative regulation of transcription from RNA polymerase II promoter
- noradrenergic neuron development
- negative regulation of protein phosphorylation
- type B pancreatic cell differentiation
- positive regulation of neural precursor cell proliferation
- regulation of gene expression
- transdifferentiation
- regulation of cell cycle
- cell migration
- regulation of cell cycle process
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- histone deacetylase binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- cyclin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- binding, bridging