Insm1 Gene Summary [Mouse]
Predicted to enable several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and cyclin binding activity. Involved in several processes, including endocrine system development; nervous system development; and norepinephrine biosynthetic process. Acts upstream of or within positive regulation of cell migration; positive regulation of cell population proliferation; and type B pancreatic cell development. Located in nucleus. Is expressed in several structures, including adrenal gland; branchial arch; gut; nervous system; and sensory organ. Orthologous to human INSM1 (INSM transcriptional repressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Insm1 |
| Official Name | insulinoma-associated 1 [Source:MGI Symbol;Acc:MGI:1859980] |
| Ensembl ID | ENSMUSG00000068154 |
| Bio databases IDs | |
| Aliases | insulinoma-associated 1 |
| Synonyms | IA-1, INSM transcriptional repressor 1, INSULINOMA ASSOCIATED 1, LOC100912563 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Insm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- small cell lung cancer
- neuroendocrine lung tumor
- small cell cervical cancer
role in cell
- apoptosis
- expression in
- proliferation
- differentiation
- binding in
- migration
- number
- cell cycle progression
- development
- transdifferentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Insm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- neuron differentiation
- negative regulation of cell proliferation
- regulation of protein complex assembly
- positive regulation of cell differentiation
- norepinephrine biosynthetic process
- adrenal chromaffin cell differentiation
- pancreatic A cell differentiation
- type B pancreatic cell development
- negative regulation of transcription from RNA polymerase II promoter
- noradrenergic neuron development
- negative regulation of protein phosphorylation
- type B pancreatic cell differentiation
- positive regulation of neural precursor cell proliferation
- regulation of gene expression
- transdifferentiation
- regulation of cell cycle
- cell migration
- regulation of cell cycle process
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- histone deacetylase binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- cyclin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- binding, bridging