Dab1 Gene Summary [Rat]
Enables phosphatidylinositol 3-kinase binding activity. Involved in midgut development; nervous system development; and response to xenobiotic stimulus. Located in apical part of cell; brush border; and neuronal cell body. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dab1 |
| Official Name | DAB adaptor protein 1 [Source:RGD Symbol;Acc:628770] |
| Ensembl ID | ENSRNOG00000007410 |
| Bio databases IDs | |
| Aliases | DAB adaptor protein 1 |
| Synonyms | AI956902, C630028C02RIK, DAB adaptor protein 1, disabled 1, LOC100502604, mDab1, SCA37, scm, scr, scrambler, yot |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dab1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- protein interaction domain
- phosphoinositide 3-kinase binding
- SH2-domain binding
- protein binding activity, bridging
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the Dab1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- coronary artery disease
- Alzheimer disease
- acute myeloid leukemia
- metabolic syndrome X
- hereditary spastic ataxia
- non-insulin-dependent diabetes mellitus
- insomnia
- idiopathic scoliosis
- streptococcal pharyngitis
role in cell
- expression in
- adhesion
- phosphorylation in
- migration
- synthesis in
- differentiation
- aggregation
- accumulation
- formation
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cell periphery
- apical compartment
- perinuclear region
- Plasma Membrane
- vesicles
- cytosol
- membrane ruffles
- growth cone
- synapse
- brush border
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dab1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte differentiation
- cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
- small GTPase mediated signal transduction
- ventral spinal cord development
- negative regulation of cell adhesion
- cerebellum structural organization
- positive regulation of neuron differentiation
- negative regulation of astrocyte differentiation
- hippocampus development
- radial glia guided migration of Purkinje cell
- negative regulation of JAK-STAT cascade
- JAK-STAT cascade
- adult walking behavior
- neuron migration
- negative regulation of axonogenesis
- axonogenesis
- Golgi localization
- dendrite development
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding