RBM4 Gene Summary [Human]
Enables RNA binding activity and cyclin binding activity. Involved in several processes, including IRES-dependent translational initiation of linear mRNA; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasmic stress granule; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RBM4 |
| Official Name | RNA binding motif protein 4 [Source:HGNC Symbol;Acc:HGNC:9901] |
| Ensembl ID | ENSG00000173933 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 4 |
| Synonyms | 4921506I22Rik, LARK, Lark1, Mlark, RBM4A, RNA binding motif protein 4, ZCCHC21, ZCRB3A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc knuckle
- RNA recognition motif (RRM) superfamily
- zinc finger
- mRNA 3' UTR binding
- RNA recognition motif
- mRNA binding
- Occluded RNA-recognition motif
- protein binding
- cyclin binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- insomnia
role in cell
- expression in
- differentiation
- alternative splicing by
- autophagy in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- enteroendocrine cell differentiation
- positive regulation of translation
- insulin secretion involved in cellular response to glucose stimulus
- negative regulation of translation involved in gene silencing by miRNA
- negative regulation of translational initiation
- cap-independent translational initiation
- negative regulation of translation in response to stress
- IRES-dependent translational initiation
- RNA processing
- regulation of insulin receptor signaling pathway
- regulation of nucleocytoplasmic transport
- nuclear mRNA splicing, via spliceosome
- circadian regulation of gene expression
- circadian regulation of translation
- regulation of alternative nuclear mRNA splicing, via spliceosome
- response to arsenic-containing substance
- entrainment of circadian clock by photoperiod
- negative regulation of translation
- positive regulation of muscle cell differentiation
- pancreas development
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasmic stress granule
- cytoplasm
- nuclear speck
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- pre-mRNA intronic binding
- zinc ion binding
- RNA binding
- protein binding
- pre-mRNA intronic pyrimidine-rich binding
- mRNA binding
- cyclin binding
- mRNA 3'-UTR binding