UBXN2A Gene Summary [Human]
Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; regulation of gene expression; and regulation of protein metabolic process. Predicted to be located in cis-Golgi network and endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | UBXN2A |
| Official Name | UBX domain protein 2A [Source:HGNC Symbol;Acc:HGNC:27265] |
| Ensembl ID | ENSG00000173960 |
| Bio databases IDs | |
| Aliases | UBX domain protein 2A |
| Synonyms | 6330407P03Rik, LOC100363283, LOC683882, UBXD4, UBX domain protein 2A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBXN2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SEP domain
- Ubl1_cv_Nsp3_N-like
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- cis Golgi networks
- medial Golgi cisternae
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBXN2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- membrane fusion
- proteasomal ubiquitin-dependent protein catabolic process
- Golgi organization
- positive regulation of protein catabolic process
- negative regulation of proteolysis
- regulation of protein ubiquitination
- nuclear envelope reassembly
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cis-Golgi network
- cytoplasm
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- perikaryon
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- acetylcholine receptor binding