Ubxn2a Gene Summary [Mouse]
Enables acetylcholine receptor binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor; regulation of protein catabolic process; and regulation of protein ubiquitination. Located in cis-Golgi network; cytosol; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; immune system; and nervous system. Orthologous to human UBXN2A (UBX domain protein 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubxn2a |
| Official Name | UBX domain protein 2A [Source:MGI Symbol;Acc:MGI:2442310] |
| Ensembl ID | ENSMUSG00000020634 |
| Bio databases IDs | |
| Aliases | UBX domain protein 2A |
| Synonyms | 6330407P03Rik, LOC100363283, LOC683882, UBXD4, UBX domain protein 2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubxn2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SEP domain
- Ubl1_cv_Nsp3_N-like
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- cis Golgi networks
- medial Golgi cisternae
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubxn2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- membrane fusion
- proteasomal ubiquitin-dependent protein catabolic process
- Golgi organization
- positive regulation of protein catabolic process
- negative regulation of proteolysis
- regulation of protein ubiquitination
- nuclear envelope reassembly
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cis-Golgi network
- cytoplasm
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- perikaryon
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- acetylcholine receptor binding