RGMB Gene Summary [Human]
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Details
| Type | Processed Transcript |
| Official Symbol | RGMB |
| Official Name | repulsive guidance molecule BMP co-receptor b [Source:HGNC Symbol;Acc:HGNC:26896] |
| Ensembl ID | ENSG00000174136 |
| Bio databases IDs | |
| Aliases | repulsive guidance molecule BMP co-receptor b |
| Synonyms | 1110059F19RIK, DRAGON, LOC285705, repulsive guidance molecule BMP co-receptor b, repulsive guidance molecule family member B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RGMB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Repulsive guidance molecule (RGM) N-terminus
- Repulsive guidance molecule (RGM) C-terminus
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- carpal tunnel syndrome
- kidney injury
- ischemia/reperfusion-induced acute kidney injury
role in cell
- expression in
- apoptosis
- quantity
- cell death
- length
- adhesion
- molecular cleavage in
- necroptosis
- injury
- osteogenic differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fimbria
- cell surface
- ER-to-Golgi intermediate compartment
- axons
- callosal axon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RGMB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- signal transduction
- BMP signaling pathway
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- membrane raft
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- identical protein binding
- protein binding