Rgmb Gene Summary [Mouse]
Enables identical protein binding activity. Involved in positive regulation of DNA-templated transcription and signal transduction. Acts upstream of or within BMP signaling pathway and cell adhesion. Located in endoplasmic reticulum-Golgi intermediate compartment and plasma membrane. Is expressed in several structures, including future brain; gut; musculoskeletal system; nervous system; and sensory organ. Orthologous to human RGMB (repulsive guidance molecule BMP co-receptor b). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgmb |
| Official Name | repulsive guidance molecule family member B [Source:MGI Symbol;Acc:MGI:1916049] |
| Ensembl ID | ENSMUSG00000048027 |
| Bio databases IDs | |
| Aliases | repulsive guidance molecule family member B |
| Synonyms | 1110059F19RIK, DRAGON, LOC285705, repulsive guidance molecule BMP co-receptor b, repulsive guidance molecule family member B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgmb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Repulsive guidance molecule (RGM) N-terminus
- Repulsive guidance molecule (RGM) C-terminus
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- carpal tunnel syndrome
- kidney injury
- ischemia/reperfusion-induced acute kidney injury
role in cell
- expression in
- apoptosis
- quantity
- cell death
- length
- adhesion
- molecular cleavage in
- necroptosis
- injury
- osteogenic differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fimbria
- cell surface
- ER-to-Golgi intermediate compartment
- axons
- callosal axon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgmb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- signal transduction
- BMP signaling pathway
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- membrane raft
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- identical protein binding
- protein binding