ZBTB4 Gene Summary [Human]
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; methyl-CpNpG binding activity; and sequence-specific DNA binding activity. Involved in cellular response to DNA damage stimulus and negative regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB4 |
| Official Name | zinc finger and BTB domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23847] |
| Ensembl ID | ENSG00000174282 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 4 |
| Synonyms | 2310026P19RIK, 9230111I22RIK, KAISO-L1, mKIAA1538, zinc finger and BTB domain containing 4, ZNF903 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBTB4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleotide binding
- protein kinase binding
- nucleic acid binding
- BTB_POZ
- zinc-finger of a C2HC-type
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- methyl-CpG binding
- protein homodimerization
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- breast cancer
- diverticular disease
- refractive error
regulated by
- benzyl isothiocyanate
- glutathione
regulates
- TP53
- reporter gene
- synthetic promoter
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear foci
- nucleoplasm
- nuclear bodies
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBTB4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein homodimerization activity
- methyl-CpNpG binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- methyl-CpG binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity