GCSAM Gene Summary [Human]
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GCSAM |
| Official Name | germinal center associated signaling and motility [Source:HGNC Symbol;Acc:HGNC:20253] |
| Ensembl ID | ENSG00000174500 |
| Bio databases IDs | |
| Aliases | germinal center associated signaling and motility, human germinal center-associated lymphoma |
| Synonyms | GCAT2, GC B CELL ASSOCIATED protein 2, GCET, GCET2, germinal center associated signaling and motility, germinal center-associated, signaling and motility, HGAL, LOC683566, M17, M17-L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GCSAM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- actin binding
- Germinal center-associated lymphoma
- myosin II binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- B-cell non-Hodgkin disease
- non-Hodgkin disease
- lymphomagenesis
- B cell cancer
- mature B-cell neoplasia
- B-cell neoplasia
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- activation in
- phosphorylation in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GCSAM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of B cell receptor signaling pathway
- negative regulation of lymphocyte migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- actin binding
- myosin II binding