IL24
IL24 Gene Summary
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL24 |
| Official Name | interleukin 24 [Source:HGNC Symbol;Acc:HGNC:11346] |
| Ensembl ID | ENSG00000162892 |
| Bio databases IDs | |
| Aliases | interleukin 24, melanoma differentiation association protein 7, suppression of tumorigenicity 16 (melanoma differentiation), IL-4-induced secreted protein |
| Synonyms | C49A,FISP,If2e,IL10B,interleukin 24,MDA7,MOB5,ST16 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- secretion/acylation domain
- signal peptide
- protein binding
- cytokine
- Interleukin 10
Pathways
Biological processes and signaling networks where the IL24 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR2
- PARP1
- TRIM37
- NOTCH2
- ATM
- HDAC1
- HRAS
- RAD51
- IL20RB
- IL22RA1
disease
- cancer
- neoplasia
- plaque psoriasis
- psoriasis
- metastatic melanoma
- metastatic melanoma cancer
- chronic kidney disease
- psoriasis like inflammation
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
regulated by
- JUN
- PRKCQ
- N-[2,2,2-trichloro-1-(2-naphthylamino)ethyl]-2-furamide
- tributyrin
- IL22
- ADORA3
- E. coli serotype 0127B8 lipopolysaccharide
- IL4
- TNF
- NIH/3T3 cells
regulates
- TNF
- IL6
- IL1B
- IL12 (complex)
- NFkB (complex)
- BAX
- IgG
- DDIT3
- EIF2S1
- synthetic promoter
role in cell
- expression in
- number
- proliferation
- differentiation
- cell death
- binding in
- apoptosis
- transactivation in
- growth
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IL24 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- signal transduction
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- cellular response to interleukin-4
- apoptotic process
- positive regulation of tyrosine phosphorylation of STAT protein
- negative regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- cytokine activity