ARIH2 Gene Summary [Human]
The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | ARIH2 |
| Official Name | ariadne RBR E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:690] |
| Ensembl ID | ENSG00000177479 |
| Bio databases IDs | |
| Aliases | ariadne RBR E3 ubiquitin protein ligase 2, all-trans retinoic acid inducible RING finger |
| Synonyms | ARI2, ariadne RBR E3 ubiquitin protein ligase 2, TRIAD1, UIP48 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARIH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBR domain, a half RING-finger domain
- In Between Ring fingers
- zinc ion binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme binding
- coiled-coil domain
- BRcat_Rcat_RBR
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Huntington disease
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- inflammatory bowel disease
- Alzheimer disease
- organismal death
- pervasive developmental disorder
- uterine leiomyoma
role in cell
- production in
- apoptosis
- proliferation
- activation in
- damage in
- ubiquitination in
- colony formation by
- function
- palbociclib resistance
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARIH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- developmental cell growth
- protein polyubiquitination
- hemopoietic stem cell proliferation
- protein K63-linked ubiquitination
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- Cul5-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding