RPS6KA5 Gene Summary [Human]
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; positive regulation of histone modification; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RPS6KA5 |
| Official Name | ribosomal protein S6 kinase A5 [Source:HGNC Symbol;Acc:HGNC:10434] |
| Ensembl ID | ENSG00000100784 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase A5 |
| Synonyms | 3110005L17RIK, 6330404E13Rik, MSK1, MSPK1, ribosomal protein S6 kinase A5, ribosomal protein S6 kinase, polypeptide 5, RLPK, RLSK, S6K-alpha-5, S6K-α-5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS6KA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- enzyme
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the RPS6KA5 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Bladder Cancer Signaling
- Circadian Rhythm Signaling
- CNTF Signaling
- ERK/MAPK Signaling
- ERK5 Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- ILK Signaling
- Melanocyte Development and Pigmentation Signaling
- mTOR Signaling
- NGF Signaling
- Opioid Signaling Pathway
- p38 MAPK Signaling
- RAR Activation
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
- UVA-Induced MAPK Signaling
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- Huntington disease
- endotoxin shock response
- prostate cancer
- major depression
- glomerulonephritis
- experimental Huntington disease
- eczema
- scleroderma
- multiple sclerosis
role in cell
- cell death
- apoptosis
- growth
- number
- activation in
- proliferation
- upregulation in
- expression in
- differentiation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- caveolae fraction
- Cytoplasm
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPS6KA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- axon guidance
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- post-translational protein modification
- positive regulation of NF-kappaB transcription factor activity
- chromatin remodeling
- inflammatory response
- negative regulation of transcription, DNA-dependent
- positive regulation of CREB transcription factor activity
- interleukin-1-mediated signaling pathway
- negative regulation of cytokine production
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- histone kinase activity (H3-S28 specific)
- histone kinase activity (H3-S10 specific)
- histone kinase activity (H2A-S1 specific)
- protein serine/threonine kinase activity