Ptpn2 Gene Summary [Mouse]
Enables STAT family protein binding activity and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of leukocyte differentiation; and regulation of signal transduction. Acts upstream of or within insulin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in nucleus. Is active in endosome lumen. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; lower jaw; and midbrain. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn2 |
| Official Name | protein tyrosine phosphatase, non-receptor type 2 [Source:MGI Symbol;Acc:MGI:97806] |
| Ensembl ID | ENSMUSG00000024539 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 2 |
| Synonyms | protein tyrosine phosphatase non-receptor type 2, protein tyrosine phosphatase, non-receptor type 2, PTN2, PTPase, Ptps, PTPT, Tc45, TCELLPTP, T CELL PTPASE, TC-PTP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- non-membrane spanning protein tyrosine phosphatase
- protein kinase binding
- protein-tyrosine-phoshatase
- catalytic domain
- Protein tyrosine phosphatase, catalytic domain
- transcription factor binding
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- DNA binding
- syntaxin binding
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- receptor tyrosine kinase binding
- integrin binding
- phosphatase
Pathways
Biological processes and signaling networks where the Ptpn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- dermatitis
- psoriasis
- rheumatoid arthritis
- inflammatory bowel disease
- Crohn disease
- prostate cancer
- diarrhea
- ulcerative colitis
- systemic lupus erythematosus
role in cell
- expression in
- activation in
- proliferation
- phosphorylation in
- growth
- generation
- survival
- differentiation
- growth in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- negative regulation of cell proliferation
- negative regulation of tyrosine phosphorylation of STAT protein
- negative regulation of epidermal growth factor receptor signaling pathway
- positive regulation of gluconeogenesis
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of macrophage differentiation
- negative regulation of interleukin-6-mediated signaling pathway
- peptidyl-tyrosine dephosphorylation
- B cell differentiation
- negative regulation of inflammatory response
- negative regulation of type I interferon-mediated signaling pathway
- insulin receptor recycling
- regulation of interferon-gamma-mediated signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of JAK-STAT cascade
- negative regulation of interferon-gamma-mediated signaling pathway
- T cell differentiation
- negative regulation of T cell receptor signaling pathway
- erythrocyte differentiation
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- glucose homeostasis
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway
- negative regulation of lipid storage
- negative regulation of chemotaxis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- endosome lumen
- cytosol
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- syntaxin binding
- integrin binding
- receptor tyrosine kinase binding