TNFSF18 Gene Summary [Human]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFSF18 |
| Official Name | TNF superfamily member 18 [Source:HGNC Symbol;Acc:HGNC:11932] |
| Ensembl ID | ENSG00000120337 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 18 |
| Synonyms | AITRL, GITRL, hGITRL, TEASRL, TL6, TNF superfamily member 18, TNLG2A, tumor necrosis factor (ligand) superfamily, member 18, tumour necrosis factor (ligand) superfamily, member 18 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFSF18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- extracellular domain
- TNF homology domain
- TNF
- protein binding
- receptor binding
- cytokine
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- activation in
- apoptosis
- proliferation
- phosphorylation in
- production in
- chemotaxis
- number
- migration
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFSF18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- positive regulation of leukocyte migration
- tumor necrosis factor-mediated signaling pathway
- signal transduction
- negative regulation of apoptotic process
- T cell proliferation involved in immune response
- cell-cell signaling
- adaptive immune response
- positive regulation of cell adhesion
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- tumor necrosis factor receptor superfamily binding
- cytokine activity
- receptor binding