TBC1D10C Gene Summary [Human]
The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | TBC1D10C |
| Official Name | TBC1 domain family member 10C [Source:HGNC Symbol;Acc:HGNC:24702] |
| Ensembl ID | ENSG00000175463 |
| Bio databases IDs | |
| Aliases | TBC1 domain family member 10C |
| Synonyms | 1810062O14Rik, CARABIN, EPI64C, RGD1311490, TBC1 domain family member 10C, TBC1 domain family, member 10C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBC1D10C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Domain in Tre-2, BUB2p, and Cdc16p
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- B-cell non-Hodgkin disease
- diffuse large B-cell lymphoma
- mature B-cell neoplasia
role in cell
- activation
- expression in
- accumulation in
- phosphorylation in
- proliferation
- formation
- formation in
- function
- degradation in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- secretory granule membrane
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBC1D10C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERK1 and ERK2 cascade
- calcineurin-NFAT signaling cascade
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of B cell activation
- negative regulation of calcineurin-NFAT signaling cascade
- B cell activation
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- filopodium membrane
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity