Tbc1d10c Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of B cell activation; negative regulation of ERK1 and ERK2 cascade; and negative regulation of calcineurin-NFAT signaling cascade. Predicted to be located in filopodium membrane. Is expressed in thymus primordium. Orthologous to human TBC1D10C (TBC1 domain family member 10C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tbc1d10c |
| Official Name | TBC1 domain family, member 10c [Source:MGI Symbol;Acc:MGI:1922072] |
| Ensembl ID | ENSMUSG00000040247 |
| Bio databases IDs | |
| Aliases | TBC1 domain family, member 10c |
| Synonyms | 1810062O14Rik, CARABIN, EPI64C, RGD1311490, TBC1 domain family member 10C, TBC1 domain family, member 10C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbc1d10c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Domain in Tre-2, BUB2p, and Cdc16p
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- B-cell non-Hodgkin disease
- diffuse large B-cell lymphoma
- mature B-cell neoplasia
role in cell
- activation
- expression in
- accumulation in
- phosphorylation in
- proliferation
- formation
- formation in
- function
- degradation in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- secretory granule membrane
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbc1d10c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERK1 and ERK2 cascade
- calcineurin-NFAT signaling cascade
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of B cell activation
- negative regulation of calcineurin-NFAT signaling cascade
- B cell activation
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- filopodium membrane
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity