AMIGO3 Gene Summary [Human]
Predicted to be involved in brain development and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AMIGO3 |
| Official Name | adhesion molecule with Ig like domain 3 [Source:HGNC Symbol;Acc:HGNC:24075] |
| Ensembl ID | ENSG00000176020 |
| Bio databases IDs | |
| Aliases | adhesion molecule with Ig like domain 3, amphoterin-induced gene and open reading frame 3 |
| Synonyms | adhesion molecule with Ig like domain 3, ALI3, E430002N15Rik, mKIAA1851 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AMIGO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- immunoglobulin domain
- Immunoglobulin like
- Leucine rich repeat
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AMIGO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron projection development
- heterophilic cell-cell adhesion
- brain development
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- membrane