Amigo3 Gene Summary [Mouse]

Acts upstream of or within positive regulation of synapse assembly. Predicted to be active in membrane. Is expressed in several structures, including brain; gut; hemolymphoid system gland; reproductive system; and trigeminal nerve. Orthologous to human AMIGO3 (adhesion molecule with Ig like domain 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Amigo3
Official Name
adhesion molecule with Ig like domain 3 [Source:MGI Symbol;Acc:MGI:2444854]
Ensembl ID
ENSMUSG00000032593
Bio databases IDs NCBI: 320844 Ensembl: ENSMUSG00000032593
Aliases adhesion molecule with Ig like domain 3
Synonyms adhesion molecule with Ig like domain 3, ALI3, E430002N15Rik, mKIAA1851
Species
Mouse, Mus musculus
OrthologiesHuman

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amigo3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • binding protein
  • immunoglobulin domain
  • Immunoglobulin like
  • Leucine rich repeat
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic musculoskeletal pain
regulated by
role in cell
  • adhesion
  • cell-cell adhesion
  • development

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Amigo3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of neuron projection development
  • heterophilic cell-cell adhesion
  • brain development
  • positive regulation of synapse assembly

Cellular Component

Where in the cell the gene product is active
  • membrane

Gene-Specific Assays for Results You Can Trust

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