HASPIN Gene Summary [Human]
Enables ATP binding activity and histone kinase activity (H3-T3 specific). Involved in histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; and mitotic sister chromatid cohesion. Located in centrosome; nucleoplasm; and spindle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HASPIN |
| Official Name | histone H3 associated protein kinase [Source:HGNC Symbol;Acc:HGNC:19682] |
| Ensembl ID | ENSG00000177602 |
| Bio databases IDs | |
| Aliases | histone H3 associated protein kinase |
| Synonyms | GSG2, GSG2 isoform 1, H-Haspin, histone H3 associated protein kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HASPIN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- protein kinase
- Protein Kinases, catalytic domain
- ATP binding
- protein binding
- enzyme
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- organismal death
role in cell
- expression in
- apoptosis
- proliferation
- formation
- formation in
- migration
- misalignment
- abnormal morphology
- cohesion
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HASPIN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- chromatin remodeling
- mitotic sister chromatid cohesion
- protein phosphorylation
- mitotic cell cycle
- protein localization to chromosome, centromeric region
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- spindle
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- histone kinase activity (H3-T3 specific)
- protein kinase activity