CD151 Gene Summary [Human]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CD151 |
| Official Name | CD151 molecule (Raph blood group) [Source:HGNC Symbol;Acc:HGNC:1630] |
| Ensembl ID | ENSG00000177697 |
| Bio databases IDs | |
| Aliases | CD151 molecule (Raph blood group) |
| Synonyms | CD151 antigen, CD151 molecule (Raph blood group), EBS7, GP27, LOC100911730, MER2, p27, PETA-3, Platelet endothelial tetraspan antigen-3, RAPH, SFA-1, TSPAN24 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD151 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoylation site
- tetraspanin_LEL
- cytoplasmic domain
- integrin binding
- protein binding
- Tetraspanin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- tubulo-interstitial fibrosis
- hyperplasia
- edema
- aortic valve calcification
- angioimmunoblastic T-cell lymphoma
- lung metastasis
role in cell
- migration
- expression in
- phosphorylation in
- growth
- activation in
- proliferation
- apoptosis
- cell viability
- function
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- membrane fraction
- actin-rich protrusion
- Cytoplasm
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- intercellular junctions
- hemidesmosomes
- cell-cell contacts
- granules
- ER-to-Golgi intermediate compartment
- cytosol
- cell membrane-lagging edges
- lateral plasma membrane
- cis face of the Golgi apparatus
- cis Golgi networks
- neurites
- early endosomes
- late endosomes
- cytoplasmic vesicles
- anchoring junction
- lateral cell-cell contacts
- membrane rafts
- cellular protrusions
- filopodia
- cell-cell adherens junctions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD151 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- positive regulation of endocytosis
- T cell proliferation
- cell adhesion
- cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- basement membrane
- focal adhesion
- membrane
- cytosol
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding