CASZ1 Gene Summary [Human]
The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | CASZ1 |
| Official Name | castor zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:26002] |
| Ensembl ID | ENSG00000130940 |
| Bio databases IDs | |
| Aliases | castor zinc finger 1, zinc finger protein 693, survival related gene |
| Synonyms | 2410019P08RIK, BC035954, CAS11, castor zinc finger 1, CST, D4Ertd432e, dJ734G22.1, LOC100041755, LOC100044758, RGD1563533, SRG, ZNF693 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CASZ1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- double-stranded DNA binding
- nucleic acid binding
- enzyme
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- adenoma formation
- tumorigenesis
- acute myeloid leukemia
- breast carcinoma
- atrial fibrillation
- cataract
- hypertension
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- differentiation
- apoptosis
- proliferation
- colony formation
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CASZ1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity