GALNT11 Gene Summary [Human]
Enables Notch binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | GALNT11 |
| Official Name | polypeptide N-acetylgalactosaminyltransferase 11 [Source:HGNC Symbol;Acc:HGNC:19875] |
| Ensembl ID | ENSG00000178234 |
| Bio databases IDs | |
| Aliases | polypeptide N-acetylgalactosaminyltransferase 11, polypeptide GalNAc transferase 11 |
| Synonyms | A430075I06Rik, E430002F06Rik, GALNAC-T11, polypeptide N-acetylgalactosaminyltransferase 11, Ppgantase t11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GALNT11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- Glycosyl transferase family 2
- Ricin-type beta-trefoil
- polypeptide N-acetylgalactosaminyltransferase
- N-terminal domain of galactosyltransferase
- beta-trefoil_Ricin_MRC-like
- enzyme
- protein binding
- Glycosyltransferase like family 2
- ricin B-type lectin domain, beta-trefoil fold
- glycosyltransferase family A
- notch binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GALNT11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- protein O-linked glycosylation
- Notch receptor processing
- regulation of Notch signaling pathway
- protein O-linked glycosylation via threonine
- O-glycan processing
- Notch signaling involved in heart development
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- Notch binding
- carbohydrate binding
- polypeptide N-acetylgalactosaminyltransferase activity