Farsa Gene Summary [Mouse]
Predicted to enable magnesium ion binding activity and phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to be part of phenylalanine-tRNA ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and respiratory system. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Farsa |
| Official Name | phenylalanyl-tRNA synthetase, alpha subunit [Source:MGI Symbol;Acc:MGI:1913840] |
| Ensembl ID | ENSMUSG00000003808 |
| Bio databases IDs | |
| Aliases | phenylalanyl-tRNA synthetase, alpha subunit |
| Synonyms | 0610012A19Rik, CML33, FARSL, FARSLA, FRSA, PheHA, Phenylalanine-tRNA synthetase-like, alpha-subunit, Phenylalanine-tRNA synthetase-like, α-subunit, phenylalanyl-tRNA synthetase, alpha subunit, phenylalanyl-tRNA synthetase subunit alpha, phenylalanyl-tRNA synthetase subunit α, phenylalanyl-tRNA synthetase, α subunit, pheRS, RILDBC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Farsa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PheRS DNA binding domain 3
- class_II_aaRS-like_core
- phenylalanyl-tRNA synthetase, alpha subunit
- HTH domain
- HTH_ARSR
- PheRS DNA binding domain 1
- enzyme
- protein binding
- magnesium ion binding
- HTH_CRP
- PheRS DNA binding domain 2
- phenylalanine-tRNA ligase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Rajab interstitial lung disease with brain calcifications 2
role in cell
- activation in
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell cortex
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Farsa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phenylalanyl-tRNA aminoacylation
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- phenylalanine-tRNA ligase complex
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- RNA binding
- protein binding
- phenylalanine-tRNA ligase activity
- tRNA binding