SH3RF1 Gene Summary [Human]
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SH3RF1 |
| Official Name | SH3 domain containing ring finger 1 [Source:HGNC Symbol;Acc:HGNC:17650] |
| Ensembl ID | ENSG00000154447 |
| Bio databases IDs | |
| Aliases | SH3 domain containing ring finger 1, plenty of SH3 domains |
| Synonyms | 2200003J05Rik, POSH, R75531, RNF142, SH3 domain containing ring finger 1, SH3MD2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SH3RF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- phosphorylation site
- Src Homology 3 domain superfamily
- MAP-kinase scaffold protein
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Siah 2 binding motif
- zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the SH3RF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- prostate cancer
- neoplasia
- Alzheimer disease
- prostatic carcinoma
- epithelial cancer
- dementia
role in cell
- expression in
- binding in
- activation in
- proliferation
- phosphorylation in
- cell death
- differentiation
- migration
- apoptosis
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- neurites
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SH3RF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- neuron migration
- regulation of CD4-positive, alpha-beta T cell differentiation
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- positive regulation of JNK cascade
- negative regulation of extrinsic apoptotic signaling pathway
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- regulation of CD8-positive, alpha-beta T cell proliferation
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
- Golgi apparatus
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- MAP-kinase scaffold activity