RAD23A Gene Summary [Human]
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | RAD23A |
| Official Name | RAD23 homolog A, nucleotide excision repair protein [Source:HGNC Symbol;Acc:HGNC:9812] |
| Ensembl ID | ENSG00000179262 |
| Bio databases IDs | |
| Aliases | RAD23 homolog A, nucleotide excision repair protein, RAD23, yeast homolog, A |
| Synonyms | 2310040P19Rik, HHR23A, HR23A, mHR23A, RAD23 homolog A, nucleotide excision repair protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAD23A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Ubiquitin family
- UV excision repair protein Rad23
- kinase binding
- single-stranded DNA binding
- protease binding
- XPC-binding domain
- Ubl1_cv_Nsp3_N-like
- ubiquitin binding domain
- Ubiquitin homologues
- protein binding
- ubiquitin-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
role in cell
- activation in
- proliferation
- degradation in
- DNA damage response
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAD23A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein destabilization
- proteasomal ubiquitin-dependent protein catabolic process
- nucleotide-excision repair
- positive regulation of cell cycle
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of viral genome replication
- regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- macromolecular complex
- proteasome complex
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- proteasome binding
- ubiquitin binding
- polyubiquitin binding
- damaged DNA binding
- kinase binding
- single-stranded DNA binding