GAS1 Gene Summary [Human]
Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GAS1 |
| Official Name | growth arrest specific 1 [Source:HGNC Symbol;Acc:HGNC:4165] |
| Ensembl ID | ENSG00000180447 |
| Bio databases IDs | |
| Aliases | growth arrest specific 1, Growth arrest-specific gene-1 |
| Synonyms | growth arrest-specific 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GAS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol binding
- N-linked glycosylation site
- protein binding
- GDNF/GAS1 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- synostosis
- microform holoprosencephaly
- brachyphalangia
- non-insulin-dependent diabetes mellitus
- uterine serous papillary cancer
- cleft palate
- lung adenocarcinoma
- lung adenocarcinoma formation
- borderline personality disorder
role in cell
- upregulation in
- apoptosis
- expression in
- proliferation
- growth
- cell cycle progression
- S phase
- cisplatin resistance
- abnormal morphology
- 5-fluorouracil resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GAS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ER to Golgi vesicle-mediated transport
- negative regulation of protein processing
- cell fate commitment
- negative regulation of mitotic cell cycle
- regulation of apoptotic process
- cellular response to vascular endothelial growth factor stimulus
- developmental growth
- regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxysterol binding